Ethyl orthoformate → Dihydroartemisinin ethyl ether

HRID 1699477

反応式

HRID 1699477 の反応式
[CH3:1][C@H:2]1[C@@H:11]2[CH2:12][CH2:13][C:14]3([CH3:18])[O:16][O:17][C@:10]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:19])[O:8][C@@H:9]4[O:15]3)[CH2:4][CH2:3]1.[CH2:21](OC(OCC)OCC)[CH3:22].[Al+3].[Cl-].[Cl-].[Cl-]>C(O)C>[CH3:21][CH2:22][O:19][C@H:7]1[O:8][C@@H:9]2[O:15][C:14]3([CH3:18])[O:16][O:17][C@@:10]42[C@@H:5]([CH2:4][CH2:3][C@@H:2]([CH3:1])[C@@H:11]4[CH2:12][CH2:13]3)[C@H:6]1[CH3:20]

参加物

5

反応物 3

HCID 31214Ethyl orthoformateHCID 456410Npc182939HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 72416Dihydroartemisinin ethyl ether

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

Dihydroartemisinin (50 mg) was dissolved in dry ethanol (3 ml). Add 2 ml of triethylorthoformate and anhydrous AlCl3 (33 mg) was added in the reaction vessel. The reaction mixture was refluxed at 40° C. for 45 min over oil bath with constant stirring. After 45 mins of stirring the reaction product was worked up as mention in the example-3. The pure arteether yielded (45 mg).

後処理

  1. additionwas added in the reaction vessel

出典と根拠

ORDレコード
ord-2c86ea0e59f7426598e4c5521edcbdaa
出典データセット
uspto-grants-2002_02
特許番号
US06346631B1

関連ノート

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