HCID 29938143、化合物 → Ethyl 3-(2,3-dihydrobenzofuran-5-yl)propanoate
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8](/[CH:10]=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][C:4]=2[CH2:3][CH2:2]1>C(O)(=O)C.[Pd]>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][C:4]=2[CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of ethyl (E)-3-(2,3-dihydrobenzofuran-5-yl)-2-propenoate (160.0 g, 733 mmols) in acetic acid (960 mL) was added 5% palladium on activated carbon (32.0 g, 50% hydrous). The mixture was stirred at 50° C. for 3.5 hours under hydrogen atmosphere (ambient pressure). The catalyst was filtered off and the filtrate containing 156.7 g (yield: 97%) of the title compound was obtained which was provided to the next step.
後処理
- filtrationThe catalyst was filtered off
出典と根拠
- ORDレコード
- ord-af9390a91e1040e09408771235e18749
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06348485B1
反応ノート
読み込み中…