Dimethylformamide → 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbonyl chloride
反応式
[CH3:1][N:2]1[C:6]([C:7]2[S:11][C:10]([C:12](O)=[O:13])=[CH:9][CH:8]=2)=[CH:5][C:4]([C:15]([F:18])([F:17])[F:16])=[N:3]1.C(Cl)(=O)C([Cl:22])=O.CN(C=O)C>ClCCCl>[CH3:1][N:2]1[C:6]([C:7]2[S:11][C:10]([C:12]([Cl:22])=[O:13])=[CH:9][CH:8]=2)=[CH:5][C:4]([C:15]([F:18])([F:17])[F:16])=[N:3]1参加物
5
実験手順
A mixture of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid, oxalyl chloride, DMF and DCE was stirred at room temperature for 90 minutes and then treated in the usual way to give 5-(1-methyl-3trifluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbonyl chloride as a brown solid.
後処理
- additiontreated in the usual way
出典と根拠
- ORDレコード
- ord-60295bd707bd44b7b71fc56ca8b93179
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06348480B1
反応ノート
読み込み中…