Hydrochloric Acid → HCID 22387805、化合物

HRID 1699802ノート

反応式

HRID 1699802 の反応式
[Cl:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1[C:6]([CH3:19])=[N:7][N:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16]CC)=[O:15])=[CH:10][C:9]=12.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1[C:6]([CH3:19])=[N:7][N:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9]=12

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18369481HCID 18369481、化合物

生成物 1

HCID 22387805HCID 22387805、化合物収率 98%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 3-(2,4-dichlorobenzyl)-2-methylpyrazolo[1,5-a]pyridine-5-carboxylate (230 mg), a 1N aqueous sodium hydroxide solution (2.0 ml) and ethanol (2.3 ml) was refluxed under heating for 25 min. The reaction mixture was adjusted to pH 4 under ice-cooling with 1N hydrochloric acid. The precipitate was collected by filtration and washed with water to give the objective compound (208 mg) as a white powder.

後処理

  1. temperatureunder heating for 25 min
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-c3025be9410c4a42acfda626e8f27bdb
出典データセット
uspto-grants-2002_02
特許番号
US06348474B1

反応ノート

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