Hydrochloric Acid → HCID 22387751、化合物

HRID 1699878ノート

反応式

HRID 1699878 の反応式
Cl.C([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)=[O:6])C.[OH-].[Na+].Cl>C(O)C>[ClH:25].[C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)([OH:6])=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388209HCID 22388209、化合物

生成物 1

HCID 22387751HCID 22387751、化合物収率 129.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

6-(Ethoxycarbonyl)-3-(2,4-dichlorobenzyl)-3,4-dihydro-2-methylquinazoline hydrochloride (0.68 g) in a mixture of a 10% aqueous sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 60° C. for 1 hr. After standing cool the reaction mixture, concentrated hydrochloric acid (5 ml) was added and the precipitate was collected by filtration. The precipitated was washed with toluene and 2-propanol and dried to give the objective compound (0.41 g) as white crystals.

後処理

  1. additionwas added
  2. filtrationthe precipitate was collected by filtration
  3. washThe precipitated was washed with toluene and 2-propanol
  4. customdried

出典と根拠

ORDレコード
ord-2ad808a9365641889d4ce5514cbede07
出典データセット
uspto-grants-2002_02
特許番号
US06348474B1

反応ノート

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