Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene
反応式
[OH:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8].[C:11](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:11][O:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8]参加物
5
反応条件
- 温度
- 20 °C
実験手順
A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.
後処理
- customthe solvent evaporated
- additionAfter addition of dichloromethane
- filtrationthe suspension is filtered
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-24f5c5162f5c49bf8082deba94f9f7e7
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06348624B1
反応ノート
読み込み中…