HCID 22181168、化合物 → 4-[(1-Methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)aniline
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:4][CH2:3]1.[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[C:18]([F:19])([F:20])[F:21])[CH2:4][CH2:3]1参加物
5
実験手順
4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethyl-1-nitrobenzene was dissolved in methanol in the presence of Pd/C. The solution was hydrogenated at 50 psi for 1 hour until hydrogen intake was completed. The catalyst was filtered off and the filtrate was concentrated to afford 4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethylbenzenamine, >95%.
後処理
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-4cb246c39a594e9eb19deff567f829c9
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06350761B1
反応ノート
読み込み中…