Trifluoroacetic acid → 2-Aminoacetanilide
反応式
FC(F)(F)C(O)=O.[C:8]1([NH:14][C:15]([CH2:17][NH:18]C(=O)OC(C)(C)C)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[NH2:18][CH2:17][C:15]([NH:14][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:16]参加物
4
実験手順
40 ml of dichloromethane and 20 ml of trifluoroacetic acid were added to 687 mg (2.74 mmol) of t-butyl phenylcarbamoylmethylcarbamate, and they were stirred at room temperature for 3 hours. Dichloromethane and trifluoroacetic acid were evaporated under reduced pressure. A saturated aqueous sodium hydrogencarbonate solution was added to the residue. After the extraction with ethyl acetate and then with dichloromethane, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.
後処理
- customDichloromethane and trifluoroacetic acid were evaporated under reduced pressure
- additionA saturated aqueous sodium hydrogencarbonate solution was added to the residue
- extractionAfter the extraction with ethyl acetate
- dry with materialwith dichloromethane, the organic layer was dried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-3e3152f295594a38a18d8080cd3cea7e
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06350762B1
反応ノート
読み込み中…