Trifluoroacetic anhydride → HCID 18317950、化合物

HRID 1700382ノート

反応式

HRID 1700382 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]([NH:21]O)=O)[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.O1CCOCC1.FC(F)(F)C(OC(=O)C(F)(F)F)=O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]#[N:21])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1

参加物

5

反応物 3

HCID 9845Trifluoroacetic anhydrideHCID 312751,4-DioxaneHCID 88186782HCID 88186782、化合物

生成物 1

HCID 18317950HCID 18317950、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

0.9 g of the compound obtained in Step B is stirred for 2 hours at ambient temperature in a solution of 10 ml of dioxane, 0.8 ml of pyridine and 0.42 ml of trifluoroacetic anhydride. After evaporating off the solvent, chromatography of the residue on silica gel (dichloromethane/ethyl acetate: 96/4) enables isolation of the expected product, which crystallises in heptane.

後処理

  1. customAfter evaporating off the solvent, chromatography of the residue on silica gel (dichloromethane/ethyl acetate: 96/4)
  2. customcrystallises in heptane

出典と根拠

ORDレコード
ord-70696473b2d2465b9711534b663ae9c3
出典データセット
uspto-grants-2002_02
特許番号
US06350757B1

反応ノート

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