Hydrazine hydrate (1:1) → 3-Methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-one

HRID 1700450ノート

反応式

HRID 1700450 の反応式
O[C:2](=[C:4]1[C:9](=O)[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[CH2:6][C:5]1=[O:18])[CH3:3].O.[NH2:20][NH2:21]>C(O)C>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH:7]1[CH2:8][C:9]2[NH:21][N:20]=[C:2]([CH3:3])[C:4]=2[C:5](=[O:18])[CH2:6]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467253HCID 178467253、化合物

生成物 1

HCID 1784341903-Methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-one収率 85.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-(1-hydroxyethylidene)-5-(2-chlorophenyl)cyclohexane-1,3-dione (0.31 g) and hydrazine hydrate (0.065 g) in ethanol (10 ml) was refluxed for 30 minutes. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.26 g).

後処理

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-4714fccebfb64bd08104b79029209840
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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