Acetone → 4-(5-Fluoro-2-methylphenyl)-3-buten-2-one

HRID 1700714ノート

反応式

HRID 1700714 の反応式
[OH-].[Na+].O.[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:12]=1)[CH:10]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:10]=[CH:14][C:15](=[O:16])[CH3:17])[CH:12]=1

参加物

5

反応物 4

HCID 180Acetone2 回HCID 962WaterHCID 14798Sodium HydroxideHCID 27590125-Fluoro-2-methylbenzaldehyde

生成物 1

HCID 540396424-(5-Fluoro-2-methylphenyl)-3-buten-2-one

実験手順

To a mixture of acetone (80 ml), sodium hydroxide (3.7 g) and water (100 ml) was added dropwise at room temperature a solution of 5-fluoro-2-methylbenzaldehyde (11.5 g) in acetone (30 ml), and the mixture was stirred at the same temperature for 1 hour. Under reduced pressure, acetone was evaporated, and the residue was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(5-fluoro-2-methylphenyl)-3-buten-2-one (13.4 g).

後処理

  1. customUnder reduced pressure, acetone was evaporated
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated brine
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-bf8e065908ac478db9dae47735935d87
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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