Acetone → 4-(2-Chloro-5-methylphenyl)-3-buten-2-one

反応式

[OH-].[Na+].O.[Cl:4][C:5]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:6]=1[CH:7]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[Cl:4][C:5]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:6]=1[CH:7]=[CH:14][C:15](=[O:16])[CH3:17]

参加物

反応物 4

HCID 180Acetone2 回

HCID 962Water

HCID 14798Sodium Hydroxide

HCID 156472782-Chloro-5-methylbenzaldehyde

生成物 1

HCID 541354784-(2-Chloro-5-methylphenyl)-3-buten-2-one

実験手順

To a mixture of acetone (160 ml), sodium hydroxide (2.6 g) and water (160 ml) was added dropwise at 0° C. a solution of crude 2-chloro-5-methylbenzaldehyde (18.3 g) in acetone (30 ml), and the mixture was stirred at the same temperature for 1 hour. Under reduced pressure, acetone was evaporated, and the residue was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(2-chloro-5-methylphenyl)-3-buten-2-one (18.9 g) as oil.