Acetone → 4-(2-Chloro-5-fluorophenyl)-3-buten-2-one
反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:5]=1[CH:6]=O.[CH3:13][C:14]([CH3:16])=[O:15]>O>[Cl:3][C:4]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:5]=1[CH:6]=[CH:13][C:14](=[O:15])[CH3:16]参加物
5
実験手順
In water (55 ml) was dissolved sodium hydroxide (0.78 g), and to the mixture was added acetone (55 ml), and then added dropwise a solution of 2-chloro-5-fluorobenzaldehyde (2.8 g) in acetone (10 ml). The reaction solution was stirred at room temperature for 2 hours, and acetone was evaporated under reduced pressure. The residue was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(2-chloro-5-fluorophenyl)-3-buten-2-one (0.24 g).
後処理
- customacetone was evaporated under reduced pressure
- extractionThe residue was extracted with ethyl acetate
- washthe organic layer was washed with water and saturated brine
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-6fd708a4a92d4e519a67e8b4383bce2f
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06350749B1
反応ノート
読み込み中…