Hydrazine → (3,4-diaMinophenyl)(Morpholino)Methanone

HRID 1701127

反応式

HRID 1701127 の反応式
[BH4-].[Na+].[N+:3]([C:6]1[CH:12]=[C:11]([C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[CH:10]=[CH:9][C:7]=1[NH2:8])([O-])=O.NN>CO>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])=[CH:12][C:6]=1[NH2:3]

参加物

5

反応物 3

HCID 9321HydrazineHCID 4311764Sodium borohydrideHCID 205537522-Nitro-4-morpholinocarbonylaniline

生成物 1

HCID 22411123(3,4-diaMinophenyl)(Morpholino)Methanone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 0.14 g of ferrous sulfate heptahydrate in 15 ml of methanol is treated under nitrogen with 0.02 g of sodium borohydride. After 5 minutes, 2.5 g of 2-nitro-4-morpholinocarbonylaniline (as prepared in Example XXXIX) and 1 ml 64% hydrazine are added. The mixture is refluxed until reduction is complete (~4-6 hours) to afford 1,2-diamino-4-morpholinocarbonylbenzene.

後処理

  1. temperatureThe mixture is refluxed until reduction
  2. custom(~4-6 hours)

出典と根拠

ORDレコード
ord-571f86fdc7104d5cb4a51a133c659b39
出典データセット
uspto-grants-1980_03
特許番号
US04191764

関連ノート

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