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Methyl iodide → HCID 53703941、化合物

HRID 1701161
ノート
印刷プレビュー

反応式

HRID 1701161 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:16]([CH2:18][C:19]([OH:21])=[O:20])=[O:17])[CH3:15])=[CH:10][CH:9]=1.[C:22](=O)([O-])[O-].[K+].[K+].CI>CS(C)=O.O.Cl>[CH3:22][O:20][C:19](=[O:21])[CH2:18][S:16]([CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[CH:9][CH:10]=1)[CH3:15])=[O:17]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 20348737HCID 20348737、化合物

生成物 1

HCID 53703941HCID 53703941、化合物

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 679Dimethyl Sulfoxide溶媒
HCID 962
Water
溶媒

実験手順

3 gm (10 millimols) of [1-(2'-fluoro-4-biphenylyl)-ethylsulfinyl]-acetic acid, m.p. 164°-165° C., were dissolved in 15 ml of dimethyl sulfoxide, 2 gm of potassium carbonate and 1.5 ml of methyl iodide were added, and the mixture was stirred at room temperature for one hour. Subsequently, the mixture was diluted with water, hydrochloric acid was added and the reaction product was extracted with ethyl acetate. After washing, drying and evaporating the extract, the residue was recrystallized from isopropanol (10 ml). Yield: 1.4 gm (44% of theory); m.p. 79° C.

後処理

  1. additionwas added
  2. extractionthe reaction product was extracted with ethyl acetate
  3. washAfter washing
  4. customdrying
  5. customevaporating the extract
  6. customthe residue was recrystallized from isopropanol (10 ml)

出典と根拠

ORDレコード
ord-e7d318cf8dcb4f3c97e488d505253218
出典データセット
uspto-grants-1980_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04191776

反応ノート

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