Thionyl Chloride → 2-(Chloromethyl)-6-(trifluoromethyl)pyridine
反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[N:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][CH:4]=1.S(Cl)([Cl:15])=O>C(Cl)Cl>[Cl:15][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:12])([F:11])[F:1])[N:8]=1参加物
4
実験手順
(6-Trifluoromethylpyridin-2-yl)methanol (760 mg, 4.3 mmol) was dissolved in CH2Cl2 and thionyl chloride was added slowly at room temperature. The reaction mixture was stirred at room temperature for 4 h. Solvent was removed under the reduced pressure, the pH was adjusted to 5, and the product was extracted with EtOAc. Purification by flash column (5% EtOAc-Hexane) gave 2-chloromethyl-6-trifluoromethylpyridine (200 mg) as a white solid.
後処理
- customSolvent was removed under the reduced pressure
- extractionthe product was extracted with EtOAc
- customPurification by flash column (5% EtOAc-Hexane)
出典と根拠
- ORDレコード
- ord-cc469430f8e64d66bc06923fb2ae540e
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737300B2
反応ノート
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