Hydrochloric Acid → 3-Bromo-4-fluorobenzyl Alcohol

HRID 1702505ノート

反応式

HRID 1702505 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](F)=[O:6].[BH4-].[Na+].Cl>C(O)(C)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[CH2:5][OH:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 129227073-Bromo-4-fluorobenzoyl fluoride

生成物 1

HCID 27733513-Bromo-4-fluorobenzyl Alcohol収率 79.5%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

221 g (1 mol) of 3-bromo-4-fluoro-benzoyl fluoride were added dropwise to a mixture of 30.4 g (0.8 mol) of sodium tetrahydridoborate and 840 ml of isopropanol at 20°-25° C. in the course of 3 hours. The reaction mixture was stirred for about a further 30 minutes and then poured into 2 liters of ice-water. The pH was adjusted to 1 by adding concentrated hydrochloric acid, and the organic layer was then separated off. The aqueous phase was subsequently extracted with 200 ml of methylene chloride. The combined organic phases were dried and filtered and the filtrate was distilled. 163 g (79.5% of theory) of 3-bromo-4-fluorobenzyl alcohol of boiling point 137° C./16 mbars and of refractive index nD20 =1.5623 were obtained.

後処理

  1. customthe organic layer was then separated off
  2. extractionThe aqueous phase was subsequently extracted with 200 ml of methylene chloride
  3. customThe combined organic phases were dried
  4. filtrationfiltered
  5. distillationthe filtrate was distilled

出典と根拠

ORDレコード
ord-9d0d5d261f1140dabd6c9548ef0ed659
出典データセット
uspto-grants-1983_04
特許番号
US04381412

反応ノート

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