5-Fluorouracil → HCID 12812862、化合物
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][N:8]=[C:9]=[O:10])=[CH:3][CH:2]=1.[F:11][C:12]1[C:13](=[O:19])[NH:14][C:15](=[O:18])[NH:16][CH:17]=1>>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]([N:16]2[CH:17]=[C:12]([F:11])[C:13](=[O:19])[NH:14][C:15]2=[O:18])=[O:10])=[CH:3][CH:2]=1参加物
3
実験手順
To the above solution of 4-pyridylmethyl isocyanate was added 5-fluorouracil (2.60 g.) at 80° C. and stirred for 4 hours at the same temperature. The resultant mixture was evaporated in vacuo. The residue was washed with diethyl ether (3 times) and crystallized. The crystals were filtered and washed with a small amount of ethanol. To the washed crystals a small amount of pyridine was added, and the mixture was warmed to be dissolved and cooled to be recrystallized. The crystals were washed successively with ethyl acetate and diethyl ether to give 1-[N-(4-pyridylmethyl)carbamoyl]-5-fluorouracil (1.75 g.)
後処理
- customThe resultant mixture was evaporated in vacuo
- washThe residue was washed with diethyl ether (3 times)
- customcrystallized
- filtrationThe crystals were filtered