Hydrogen Bromide → Phenol, 4-(4-(methylsulfonyl)phenoxy)-

HRID 1702825

反応式

HRID 1702825 の反応式
[CH3:1][S:2]([C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].Br>C(O)(=O)C>[CH3:1][S:2]([C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 514881Benzene, 1-methoxy-4-(4-(methylsulfonyl)phenoxy)-

生成物 1

HCID 514882Phenol, 4-(4-(methylsulfonyl)phenoxy)-収率 98.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 37.3 g of 4-(4-(methylsulfonyl)phenoxy)-1-methoxybenzene (Example 18), 41 ml of 48% aqueous hydrogen bromide and 185 ml of glacial acetic acid was heated at reflux under nitrogen for 21 hrs. The reaction mixture was cooled and the solvent removed in vacuo. The product was collected by filtration, washed well with water and dried, which gave 35.0 g (98.9% yield) of the product. Recrystallization from aqueous ethanol gave purified 4-(4-(methylsulfonyl)phenoxy)phenol, mp 129°-130° C.

後処理

  1. temperatureat reflux under nitrogen for 21 hrs
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent removed in vacuo
  4. filtrationThe product was collected by filtration
  5. washwashed well with water
  6. customdried

出典と根拠

ORDレコード
ord-1acd3a1bdd854cf59d611823204970f6
出典データセット
uspto-grants-1982_09
特許番号
US04349568

関連ノート

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