Dimethyl Sulfate → N-methyl-1-(4-isopropylphenyl) ethylamine

HRID 1702958

反応式

HRID 1702958 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([NH2:12])[CH3:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+].S(OC)(O[CH3:19])(=O)=O>O>[CH3:19][NH:12][CH:10]([C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)[CH3:11]

参加物

5

反応物 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 37280391-(4-Isopropylphenyl)ethanamine

生成物 1

HCID 20120487N-methyl-1-(4-isopropylphenyl) ethylamine収率 69.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of 1-(4-isopropylphenyl) ethylamine (81 g) was stirred vigorously in a solution of sodium hydroxide (50 g) in water (250 ml) at room temperature. Dimethyl sulphate (64 g) was added dropwise to the stirred suspension over a period of 1 hour. The suspension was stored in a refrigerator overnight and three layers were formed. The top layer of organic material was extracted with ether and the ether solution was separated and dried over anhydrous magnesium sulphate. The ether was evaporated under reduced pressure to give a yellow oil which was distilled at a water pump to give N-methyl-1-(4-isopropylphenyl) ethylamine (61 g, 69%) colourless oil, boiling point 112° to 114° C./20 mm.

後処理

  1. customwas stored in a refrigerator overnight
  2. customthree layers were formed
  3. extractionThe top layer of organic material was extracted with ether
  4. customthe ether solution was separated
  5. dry with materialdried over anhydrous magnesium sulphate
  6. customThe ether was evaporated under reduced pressure
  7. customto give a yellow oil which
  8. distillationwas distilled at a water pump

出典と根拠

ORDレコード
ord-3faef86d4e704d90bdf022d16c0a6523
出典データセット
uspto-grants-1982_09
特許番号
US04350644

関連ノート

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