Hydrazine hydrate (1:1) → HCID 20497519、化合物

HRID 1702980ノート

反応式

HRID 1702980 の反応式
SC1N(C)C(=O)C2C(=CC=C(C)C=2)[N:3]=1.ClC1N=C(O)C2C(=CC=C(C)C=2)N=1.[NH:28]([C:30]1[N:39]=[C:38]([OH:40])[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([CH3:41])[CH:36]=2)[N:31]=1)[NH2:29].SC1N=C(O)C2C(=CC=C(C)C=2)N=1.O.NN>O>[NH2:3][N:39]1[C:38](=[O:40])[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([CH3:41])[CH:36]=2)[N:31]=[C:30]1[NH:28][NH2:29]

参加物

7

反応物 5

HCID 24654Hydrazine hydrate (1:1)HCID 178423383HCID 178423383、化合物HCID 178423437HCID 178423437、化合物HCID 178423445HCID 178423445、化合物HCID 178423447HCID 178423447、化合物

生成物 1

HCID 20497519HCID 20497519、化合物収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-mercapto-3,6-dimethylquinazolin-4(3H)-one, 2-chloro-6-methylquinazolin-4-ol, 2-hydrazino-6-methylquinazolin-4-ol or 2-mercapto-6-methylquinazolin-4-ol was stirred in 5 volumes of hydrazine hydrate at reflux for 24 hours and the mixture was diluted with 5 volumes of water. The mixture was cooled to room temperature and was filtered. The product was washed with water and then methanol and dried to obtain a 95% yield of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one.

後処理

  1. temperatureat reflux for 24 hours
  2. filtrationwas filtered
  3. washThe product was washed with water
  4. dry with materialmethanol and dried

出典と根拠

ORDレコード
ord-eebe994ffe734c2b84796ca6cb1e5426
出典データセット
uspto-grants-1982_09
特許番号
US04350695

反応ノート

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