Hydrochloric Acid → (1,4-Diazepan-1-yl)(furan-2-yl)methanone
反応式
[NH:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl.[O:9]1[CH:13]=[CH:12][CH:11]=[C:10]1[C:14](Cl)=[O:15].[OH-].[Na+]>O>[O:9]1[CH:13]=[CH:12][CH:11]=[C:10]1[C:14]([N:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)=[O:15]参加物
6
実験手順
Homopiperazine (70 g., 0.70 mole) in 160 ml. water was treated with 6 N hydrochloric acid to adjust to pH 5.5 Furoyl chloride (79.5 g., 0.60 mole) and 25% (w/w) aqueous sodium hydroxide solution were added simultaneously to maintain a pH of 4.5-5.5. Then additional sodium hydroxide was added to bring the mixture to pH 9.5. The solution was extracted with chloroform, dried over anhydrous potassium carbonate and distilled to afford 63 g. of product, B.P. 124°-130° C. at 10 mm.
後処理
- additionwere added simultaneously
- temperatureto maintain a pH of 4.5-5.5
- extractionThe solution was extracted with chloroform
- dry with materialdried over anhydrous potassium carbonate
- distillationdistilled
- customto afford 63 g
出典と根拠
- ORDレコード
- ord-497c6fabe0124a15969c17ee38de26a5
- 出典データセット
- uspto-grants-1982_09
- 特許番号
- US04351940
反応ノート
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