Iodine → 3,5-Bis(trifluoromethyl)chlorobenzene

HRID 1703406

反応式

HRID 1703406 の反応式
ClS(O)(=O)=O.[F:6][C:7]([F:19])([F:18])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=1.II.[Cl:22]Cl>>[Cl:22][C:12]1[CH:11]=[C:10]([C:14]([F:15])([F:16])[F:17])[CH:9]=[C:8]([C:7]([F:18])([F:19])[F:6])[CH:13]=1

参加物

5

反応物 4

HCID 807IodineHCID 24526ChlorineHCID 24638Chlorosulfonic acidHCID 223106Benzene, 1,3-bis(trifluoromethyl)-

生成物 1

HCID 27694053,5-Bis(trifluoromethyl)chlorobenzene

実験手順

130 parts of chlorosulfonic acid are introduced, at room temperature, into a reaction vessel, and 42.8 parts of 1,3-bis-(trifluoromethyl)-benzene and 2 parts of iodine are added. The suspension is cooled to 0° and 30 parts of chlorine are introduced in the course of 5 hours at 0° to 5°. The suspension is then poured out onto ice and the organic phase is separated from the aqueous phase. The organic phase is washed neutral with ice-cold water and is dried over calcined sodium sulfate. 38 parts of 5-chloro-1,3-bis-(trifluoromethyl)-benzene, of boiling point 111° to 112°, are obtained.

後処理

  1. temperatureThe suspension is cooled to 0°
  2. additionThe suspension is then poured out onto ice
  3. customthe organic phase is separated from the aqueous phase
  4. washThe organic phase is washed neutral with ice-cold water
  5. customis dried

出典と根拠

ORDレコード
ord-1c39f0b0e3bf43ec819efe7bdeace7cc
出典データセット
uspto-grants-1982_09
特許番号
US04351975

関連ノート

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