2-(Chloromethyl)-1-ethyl-4-nitrobenzene → 4-Ethyl-3-methylaniline
反応式
Cl[CH2:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[CH2:12][CH3:13].[H][H]>C(O)(=O)C.[Pd]>[CH2:12]([C:4]1[CH:5]=[CH:6][C:7]([NH2:9])=[CH:8][C:3]=1[CH3:2])[CH3:13]参加物
5
実験手順
α-Chloro-2-ethyl-5-nitrotoluene (40.0 g.) was dissolved in glacial acetic acid and shaken with 5% Pd/C in a hydrogen atmosphere (6.7 g.) in a Parr hydrogenator. When reduction was complete, the crude product was isolated, taken up in ether, washed with water, dilute base and water. After stirring the ether solution over solid K2CO3, the product was isolated as a liquid, 96% pure by glc.
出典と根拠
- ORDレコード
- ord-4d0ff86dcd1b402c95de2138df8f2bae
- 出典データセット
- uspto-grants-1978_11
- 特許番号
- US04124639
反応ノート
読み込み中…