Water → 7-Bromo-5-methyl-3-phenylbenzofuran

HRID 1703558

反応式

HRID 1703558 の反応式
[Br:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.O>C(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([CH3:18])[CH:17]=1

参加物

4

反応物 2

HCID 962WaterHCID 40772362-(2-Bromo-4-methylphenoxy)acetophenone

生成物 1

HCID 213199287-Bromo-5-methyl-3-phenylbenzofuran

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 700 g. of polyphosphoric acid and 100 g. of α-(2-bromo-4-methylphenoxy)acetophenone is heated at 80°-90° C. for two hours, then poured into two liters of water with stirring. Chloroform (1 liter) is added, and the phases are separated. The organic layer is washed with water, dried, then evaporated to provide 7-bromo-5-methyl-3-phenylbenzofuran as a brown oil.

後処理

  1. additionA mixture of 700 g
  2. customthe phases are separated
  3. washThe organic layer is washed with water
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-cae0c244fee247488e81e68e0fc2c5a9
出典データセット
uspto-grants-1978_11
特許番号
US04124704

関連ノート

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