Hydrochloric Acid → 4-Bromo-3-sulfamoylbenzoyl chloride

HRID 1703880ノート

反応式

HRID 1703880 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[ClH:15]>S(Cl)(Cl)=O.O1CCOCC1>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 5542164-Bromo-3-sulfamoylbenzoic acid

生成物 1

HCID 213166124-Bromo-3-sulfamoylbenzoyl chloride

試薬・触媒・溶媒 2

HCID 24386Thionyl Chloride溶媒HCID 312751,4-Dioxane溶媒

実験手順

10 g of 4-bromo-3-sulfamoylbenzoic acid were heated under reflux in a mixture of 80 ml of thionyl chloride and 50 ml of dioxane until HCl had completely developped. Then, the reaction mixture was concentrated under reduced pressure to 40 ml, 200 ml of petroleum ether were added and the crystals were filtered off. Melting point: 138° C. (decomposition).

後処理

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure to 40 ml, 200 ml of petroleum ether
  2. additionwere added
  3. filtrationthe crystals were filtered off

出典と根拠

ORDレコード
ord-d42cd553cdb646c492534e1fcb642ddf
出典データセット
uspto-grants-1978_11
特許番号
US04125614

反応ノート

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