Hydrochloric Acid → HCID 22760436、化合物

HRID 1703922ノート

反応式

HRID 1703922 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:17])(=[O:16])[N:13]([CH3:15])[CH3:14])[CH:6]=1)=[O:4].[BH4-].[Na+].Cl>CO>[Br:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:16])(=[O:17])[N:13]([CH3:14])[CH3:15])[CH:6]=1)[OH:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 204768462-Bromo-4'-chloro-3'-dimethylsulfamoylacetophenone

生成物 1

HCID 22760436HCID 22760436、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of 6.4 g of 2-bromo-4'-chloro-3'-dimethylsulfamoylacetophenone in 28 ml of methanol were added dropwise, at a reaction temperature of 5° C., a solution of 0.6 g of sodium borohydride in 5 ml of methanol and the solution was then stirred for 1 hour at room temperature. The reaction mixture was acidified while cooling (+5° C.) with 2 N HCl and the solvent was distilled off under reduced pressure. After adding 70 ml of water, extraction followed with 200 ml of diethyl ether, the organic phase was dried over sodium sulfate, the solvent was distilled off and 2-bromo-1-(4-chloro-3-dimethylsulfamoylphenyl)-ethanol was obtained as fair yellow to colorless oil.

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionAfter adding
  3. extraction70 ml of water, extraction
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-80c5472a3317450a8bf6655fa0b21dcf
出典データセット
uspto-grants-1978_11
特許番号
US04125614

反応ノート

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