Benzyl Chloride → 4-Benzyloxy-alpha-ethyldesoxybenzoin

HRID 1706166ノート

反応式

HRID 1706166 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]([CH2:17][CH3:18])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:25](Cl)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(O)C.O.[I-].[K+]>[CH2:25]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH:10]([CH2:17][CH3:18])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:9])=[CH:6][CH:7]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

7

反応物 3

HCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 2272781-(4-Hydroxyphenyl)-2-phenylbutan-1-one

生成物 1

HCID 189765134-Benzyloxy-alpha-ethyldesoxybenzoin

試薬・触媒・溶媒 3

HCID 4875Potassium Iodide触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 4-hydroxy-α-ethyldesoxybenzoin (44.5 g.), sodium carbonate (18.5 g.), potassium iodide (1.4 g.) and benzyl chloride (19 ml.) in ethanol (350 ml.) and water (50 ml.) was stirred and heated under reflux for 8 hours. The mixture was cooled, filtered and the residue washed with water to give 4-benzyloxy-α-ethyldesoxybenzoin (54.3 g.), m.p. 71° C.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. washthe residue washed with water

出典と根拠

ORDレコード
ord-528364d8dd7c4792bab41a8275fa4036
出典データセット
uspto-grants-1980_06
特許番号
US04206234

反応ノート

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