Formic Acid → Fosmidomycin

HRID 1706221

反応式

HRID 1706221 の反応式
[OH:1][NH:2][CH2:3][CH2:4][CH2:5][P:6](=[O:9])([OH:8])[OH:7].[C:10](OC(=O)C)(=[O:12])C.C(O)=O.[OH-].[Mg+2].[OH-]>O>[CH:10]([N:2]([CH2:3][CH2:4][CH2:5][P:6](=[O:8])([OH:7])[OH:9])[OH:1])=[O:12]

参加物

6

反応物 4

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 73981Magnesium HydroxideHCID 3421703-(Hydroxyamino)propylphosphonic acid

生成物 1

HCID 572Fosmidomycin収率 65.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.

後処理

  1. temperaturecooling

出典と根拠

ORDレコード
ord-d0d185827fa64e5797039853d4dfd715
出典データセット
uspto-grants-1980_06
特許番号
US04206156

関連ノート

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