Sodium Hydroxide → 1,2-Dihydroxycyclohexanemethanol

HRID 1706301ノート

反応式

HRID 1706301 の反応式
[O:1]1[CH:3]2[CH2:4][CH2:5][CH2:6][CH2:7][C:2]12[CH2:8][OH:9].[OH-:10].[Na+]>S(=O)(=O)(O)O.O1CCOCC1.O>[OH:10][C:2]1([CH2:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[OH:1]

参加物

6

反応物 2

HCID 14798Sodium HydroxideHCID 141075391,2-Epoxycyclohexanemethanol

生成物 1

HCID 203346281,2-Dihydroxycyclohexanemethanol

試薬・触媒・溶媒 3

HCID 1118Sulfuric Acid触媒HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

A stirred mixture of 10.6 g of 1,2-epoxycyclohexanemethanol and 8 drops of concentrated sulfuric acid in 100 ml of p-dioxane and 100 ml of water was heated at 60°-70° for 18 hours. The reaction mixture was neutralized with sodium hydroxide, and evaporated under reduced pressure to a viscous residue. The residue was taken up in methanol and dried with sodium sulfate. The mixture was filtered and the filtrate evaporated under reduced pressure to a residue. The residue was distilled to give 10.8 g of 1,2-dihydroxycyclohexanemethanol; bp 170°-240°/0.02 mm. The nmr spectrum was consistent with the assigned structure.

後処理

  1. temperaturewas heated at 60°-70° for 18 hours
  2. customevaporated under reduced pressure to a viscous residue
  3. dry with materialdried with sodium sulfate
  4. filtrationThe mixture was filtered
  5. customthe filtrate evaporated under reduced pressure to a residue
  6. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-cc341d71c45a4fceb73d0de65817dbfa
出典データセット
uspto-grants-1980_06
特許番号
US04207088

反応ノート

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