Methyl acetoacetate → 3-Furancarboxylic acid, 2,5-dimethyl-, methyl ester

HRID 1706338

反応式

HRID 1706338 の反応式
[C:1]([O:4][CH:5]([CH3:8])[CH:6]=O)(=O)[CH3:2].[C:9]([O:15][CH3:16])(=[O:14])[CH2:10]C(C)=O>[Fe].CO>[CH3:16][O:15][C:9]([C:10]1[CH:6]=[C:5]([CH3:8])[O:4][C:1]=1[CH3:2])=[O:14]

参加物

5

反応物 2

HCID 7757Methyl acetoacetateHCID 907282-(Acetyloxy)propanal

生成物 1

HCID 802483-Furancarboxylic acid, 2,5-dimethyl-, methyl ester

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 887Methanol溶媒

実験手順

27 parts by weight of iron-III chloride and 149 parts by weight of 85.5 percent strength α-acetoxypropionaldehyde are added to a solution of 116 parts by weight of methyl acetoacetate in 120 parts by weight of methanol at a rate such that the mixture rises to the boil. The methanol is distilled off under atmospheric pressure and the product is then distilled under reduced pressure. 106.2 parts by weight of 2,5-dimethylfuran-3-carboxylic acid methyl ester, of boiling point 89° C./20 mbar, are obtained.

後処理

  1. distillationThe methanol is distilled off under atmospheric pressure
  2. distillationthe product is then distilled under reduced pressure

出典と根拠

ORDレコード
ord-c8642babbd0f4c62b60da3f1892d1dd2
出典データセット
uspto-grants-1980_06
特許番号
US04207243

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