p-Toluenesulfonic acid → 6-Acetoxy-2-naphthyl-alpha-methylacetic acid

HRID 1706575ノート

反応式

HRID 1706575 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:6]=[CH:5]2.[C:17](OC(=O)C)(=[O:19])[CH3:18].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[C:17]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:6]=[CH:5]2)(=[O:19])[CH3:18]

参加物

4

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 7918Acetic AnhydrideHCID 162920Desmethylnaproxen

生成物 1

HCID 203351926-Acetoxy-2-naphthyl-alpha-methylacetic acid

実験手順

A mixture of 2.2 g. of 6-hydroxy-2-naphthyl-α-methylacetic acid, 50 ml. of acetic anhydride, and 100 mg. of p-toluenesulfonic acid is stirred for four hours at 50° C. The mixture is evaporated, water is added, and the mixture is extracted with diethyl ether which is washed with water to neutrality, dried over sodium sulfate, and evaporated to yield 6-acetoxy-2-naphthyl-α-methylacetic acid.

後処理

  1. additionA mixture of 2.2 g
  2. customThe mixture is evaporated
  3. additionwater is added
  4. extractionthe mixture is extracted with diethyl ether which
  5. washis washed with water to neutrality
  6. dry with materialdried over sodium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-82dfb422a80b4955bd65941467579a11
出典データセット
uspto-grants-1980_06
特許番号
US04207241

反応ノート

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