Ethanol → 4-(4-Methoxybenzyl)benzoic acid
反応式
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[OH-].[Na+].C(O)C>O>[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1参加物
5
実験手順
A mixture of 120 g. of ethyl 4-(4-methoxybenzyl)benzoate, 500 ml. of 2 N sodium hydroxide solution and 250 ml. of ethanol was heated at reflux for two hours. The reaction mixture was cooled, diluted with water and extracted with ether. The aqueous layer was acidified with hydrochloric acid and the precipitate which formed was collected and dried to give 100 g. of 4-(4-methoxybenzyl)benzoic acid, m.p. 152°-153° C. when recrystallized from aqueous ethanol.
後処理
- additionA mixture of 120 g
- temperatureat reflux for two hours
- temperatureThe reaction mixture was cooled
- extractionextracted with ether
- customthe precipitate which formed
- customwas collected
- customdried
- customto give 100 g
- customof 4-(4-methoxybenzyl)benzoic acid, m.p. 152°-153° C. when recrystallized from aqueous ethanol
出典と根拠
- ORDレコード
- ord-2b69c729785f44bdb2ec8bd9255847ce
- 出典データセット
- uspto-grants-1980_06
- 特許番号
- US04208425
反応ノート
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