Ethanol → 4-(4-Methoxybenzyl)benzoic acid

HRID 1706697

反応式

HRID 1706697 の反応式
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[OH-].[Na+].C(O)C>O>[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 12463843Ethyl 4-(4-methoxybenzyl)benzoate

生成物 1

HCID 2579874-(4-Methoxybenzyl)benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 120 g. of ethyl 4-(4-methoxybenzyl)benzoate, 500 ml. of 2 N sodium hydroxide solution and 250 ml. of ethanol was heated at reflux for two hours. The reaction mixture was cooled, diluted with water and extracted with ether. The aqueous layer was acidified with hydrochloric acid and the precipitate which formed was collected and dried to give 100 g. of 4-(4-methoxybenzyl)benzoic acid, m.p. 152°-153° C. when recrystallized from aqueous ethanol.

後処理

  1. additionA mixture of 120 g
  2. temperatureat reflux for two hours
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted with ether
  5. customthe precipitate which formed
  6. customwas collected
  7. customdried
  8. customto give 100 g
  9. customof 4-(4-methoxybenzyl)benzoic acid, m.p. 152°-153° C. when recrystallized from aqueous ethanol

出典と根拠

ORDレコード
ord-2b69c729785f44bdb2ec8bd9255847ce
出典データセット
uspto-grants-1980_06
特許番号
US04208425

関連ノート

読み込み中…