HCID 22850442、化合物 → HCID 18963415、化合物

HRID 1707362ノート

反応式

HRID 1707362 の反応式
[C:1]([O:6][C:7]1=[CH:8][C:9](=[O:16])[NH:10]/[C:11]/1=[CH:12]\[CH:13]([CH3:15])[CH3:14])(=[O:5])[CH2:2][CH2:3][CH3:4]>C1(C)C=CC=CC=1.[Pd]>[C:1]([O:6][CH:7]1[CH:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[NH:10][C:9](=[O:16])[CH2:8]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 22850442HCID 22850442、化合物

生成物 1

HCID 18963415HCID 18963415、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 1140Toluene溶媒

実験手順

30.0 g of (Z)-4-butyryloxy-5-isobutylidene-3-pyrrolin-2-one (produced according to Example 3) was dissolved in 300 ml of toluene, mixed with 3.0 g of palladium/activated carbon(5 percent of pf Pd) and hydrogenated for 24 hours in an autoclave at 2 MPa (20 bar). Then the catalyst was filtered off, the filtrate was concentrated by evaporation and the residue was recrystallized from hexane. The yield of the title compound was 23.50 g (77 percent of theory). The title compound had a melting point of 101.5° to 102.7° C. Other data concerning the title compound was:

後処理

  1. filtrationThen the catalyst was filtered off
  2. concentrationthe filtrate was concentrated by evaporation
  3. customthe residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-25eeba19e90e4db78d7ba0b5c2c71aa1
出典データセット
uspto-grants-1994_10
特許番号
US05352801

反応ノート

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