1-[2-(4-Pyridinyl)ethyl]piperazine → 8-Chloro-10,11-dihydro-10-[[4-[2-(4-pyridinyl)ethyl]-1-piperazinyl]carbonyl]dibenz[b,f][1,4]oxazepine

HRID 1707645

反応式

HRID 1707645 の反応式
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[N:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:31]3[CH2:32][CH2:33][N:28]([CH2:27][CH2:26][C:23]4[CH:22]=[CH:21][N:20]=[CH:25][CH:24]=4)[CH2:29][CH2:30]3)=[O:12])[C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 5586851-[2-(4-Pyridinyl)ethyl]piperazineHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

生成物 1

HCID 152249268-Chloro-10,11-dihydro-10-[[4-[2-(4-pyridinyl)ethyl]-1-piperazinyl]carbonyl]dibenz[b,f][1,4]oxazepine収率 291.3%

実験手順

The title compound of Example 2 (0.38 g, 1.3 mmol) was combined with the product of Example 88 (0.25 g, 1.3 mmol) and the reaction was carried out by the method of Example 4. Following chromatographic separation, 1.7 g of the white solid title product was obtained.

後処理

  1. customseparation

出典と根拠

ORDレコード
ord-525a2e45e5144ec48c3316b67909b848
出典データセット
uspto-grants-1994_10
特許番号
US05354747

関連ノート

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