Phosgene → 8-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

HRID 1707650ノート

反応式

HRID 1707650 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[Cl:5][C:6]1[CH:20]=[CH:19][C:9]2[S:10][C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][NH:14][C:8]=2[CH:7]=1.C(N(CC)CC)C>O1CCCC1>[Cl:5][C:6]1[CH:20]=[CH:19][C:9]2[S:10][C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][N:14]([C:1]([Cl:4])=[O:2])[C:8]=2[CH:7]=1

参加物

5

反応物 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 542201108-Chloro-10,11-dihydrodibenzo[b,f][1,4]thiazepine

生成物 1

HCID 229217168-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a cold (ice-H2O bath), stirred solution of phosgene (1.93M in toluene; 8.6 mL) in anhydrous tetrahydrofuran (40 mL) under a nitrogen atmosphere is added, dropwise, a solution of the product of Example 104 (8-chloro-10,11-dihydrodibenzo[b,f][1,4]thiazepine) (2.00 g) and triethylamine (1.3 mL) in anhydrous tetrahydrofuran (30 mL). The resulting mixture is stirred at room temperature for 90 minutes, and the solvent is then evaporated in vacuo to provide the title product.

後処理

  1. additionis added
  2. customthe solvent is then evaporated in vacuo

出典と根拠

ORDレコード
ord-a7791d8f8ad94dac93a51d96ca426dcc
出典データセット
uspto-grants-1994_10
特許番号
US05354747

反応ノート

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