Ethanol → Etilevodopa

HRID 1707794

反応式

HRID 1707794 の反応式
[CH:1]1[C:6]([CH2:7][C@H:8]([NH2:12])[C:9]([OH:11])=[O:10])=[CH:5][C:4]([OH:13])=[C:3]([OH:14])[CH:2]=1.S(Cl)(Cl)=O.[CH2:19](O)[CH3:20]>>[CH3:19][CH2:20][O:10][C:9]([C@@H:8]([NH2:12])[CH2:7][C:6]1[CH:1]=[CH:2][C:3]([OH:14])=[C:4]([OH:13])[CH:5]=1)=[O:11]

参加物

4

反応物 3

HCID 702EthanolHCID 6047LevodopaHCID 24386Thionyl Chloride

生成物 1

HCID 170345Etilevodopa

反応条件

温度
5 °C

実験手順

Levodopa (50 g.) was added in portions to a cooled (2-8° C.) solution of 30 ml. thionyl chloride in 250 ml. absolute ethanol. The resulting mixture was heated to 40° C. for 16 hours and then the volatiles were removed in vacuo. The residue was dissolved in 50 ml. of water and diluted with a solution of 20 g. of sodium bicarbonate, 26 g. of sodium sulfate and 50 mg. of ascorbic acid in 400 ml. of water. The pH of the resulting solution was carefully adjusted to pH 7 with 10% aqueous sodium hydroxide and it was extracted with deaerated free ethyl acetate containing 0.01% BHT.

後処理

  1. temperatureThe resulting mixture was heated to 40° C. for 16 hours
  2. customthe volatiles were removed in vacuo
  3. dissolutionThe residue was dissolved in 50 ml
  4. additionof water and diluted with a solution of 20 g
  5. extractionwas extracted with deaerated free ethyl acetate containing 0.01% BHT

出典と根拠

ORDレコード
ord-3edbbe75c9014aed894cc135a18f0142
出典データセット
uspto-grants-1994_10
特許番号
US05354885

関連ノート

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