Water → 1-Ethynyl-4-pentylbenzene

HRID 1707887ノート

反応式

HRID 1707887 の反応式
CC(O)(C)[C:3]#[C:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:7][CH:6]=1.[H-].[Na+].O>C1(C)C=CC=CC=1>[CH2:11]([C:8]1[CH:7]=[CH:6][C:5]([C:4]#[CH:3])=[CH:10][CH:9]=1)[CH2:12][CH2:13][CH2:14][CH3:15]

参加物

5

反応物 3

HCID 962WaterHCID 24758Sodium hydrideHCID 189600502-Methyl-4-(4-pentylphenyl)-3-butyn-2-ol

生成物 1

HCID 27751311-Ethynyl-4-pentylbenzene収率 78.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
60 °C

実験手順

3-Methyl-1-(4'-pentylphenyl)-1-butyne-3-ol (82 g) was dissolved in toluene (900 ml) under nitrogen atmosphere, and then sodium hydride (60% in paraffin liquid; 5.6 g) was added thereto, followed by stirring at 60° C. for 6 hours. The reaction solution was poured into water (500 ml), and extracted with chloroform, followed by washing with water three times. After distilling off toluene and chloroform, the resultant was distilled under reduced pressure (b.p. 85° to 90° C./3 mmHg) to give 4-pentylphenylacetylene (48 g).

後処理

  1. extractionextracted with chloroform
  2. washby washing with water three times
  3. distillationAfter distilling off toluene and chloroform
  4. distillationthe resultant was distilled under reduced pressure (b.p. 85° to 90° C./3 mmHg)

出典と根拠

ORDレコード
ord-38f07c5ccb884bc3b6fdd552c381312b
出典データセット
uspto-grants-1994_10
特許番号
US05356558

反応ノート

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