Acetic Acid → N-(tert-Butyl)-1H-pyrrole-3-sulfonamide

HRID 1707929

反応式

[CH3:1][C:2]([NH:5][S:6]([C:9]1[CH:13]=[CH:12][N:11]([Si](C(C)C)(C(C)C)C(C)C)[CH:10]=1)(=[O:8])=[O:7])([CH3:4])[CH3:3].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.C1COCC1.C(O)(=O)C>C1COCC1>[CH3:4][C:2]([NH:5][S:6]([C:9]1[CH:13]=[CH:12][NH:11][CH:10]=1)(=[O:8])=[O:7])([CH3:1])[CH3:3]

参加物

実験手順

A solution of N-(1,1-dimethylethyl)-1-[tris(1-methylethyl)sily]-1H-pyrrole-3-sulfonamide (1.7 g, 4.7 mmol) in 25 mL THF was treated with 5.2 mL of 1M tetrabutylammonium fluoride/THF solution, followed by 0.3 mL of acetic acid. After stirring 30 minutes at room temperature, the reaction mixture was filtered through silica with THF rinse, and the filtrate stripped. The solid residue was triturated with hexanes to afford 0.77 g of tan solids, m.p. 145°-147° C. dec.

後処理

filtrationthe reaction mixture was filtered through silica with THF
washrinse
customThe solid residue was triturated with hexanes

出典と根拠

ORDレコード: ord-5d832ec7db804cc5a611aa6687b957c7
出典データセット: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05356862

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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