HCID 14654393、化合物 → cis-Azetidine-2,4-dicarboxylic acid
反応式
C([O:8][C:9]([C@H:11]1[CH2:14][C@@H:13]([C:15]([O:17]CC2C=CC=CC=2)=[O:16])[N:12]1CC1C=CC=CC=1)=[O:10])C1C=CC=CC=1>CO.O.[Pd]>[NH:12]1[C@H:13]([C:15]([OH:17])=[O:16])[CH2:14][C@@H:11]1[C:9]([OH:10])=[O:8]参加物
5
実験手順
208 mg (0.5 mmol) of stereochemically pure transor cis-N-benzylazetidine-2,4-dicarboxylic acid dibenzyl ester and 20 mg of 10% Pd/C in 15 ml of methanol are hydrogenated as above. The reaction mixture is diluted with 50 ml of warm water, filtered, and evaporated to dryness to afford as off-white solids the trans- or cis azetidine-2,4-dicarboxylic acid in virtually quantitative yield.
後処理
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-ed044c78b168470f82ce54ea04463e71
- 出典データセット
- uspto-grants-1990_08
- 特許番号
- US04946839
反応ノート
読み込み中…