Hydrochloric Acid → Mdl-27192

HRID 1708907ノート

反応式

HRID 1708907 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])=O)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]2[N:12]([CH2:13][CH3:14])[C:10](=[O:11])[NH:9][N:8]=2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13864336HCID 13864336、化合物

生成物 1

HCID 35793Mdl-27192

実験手順

1-(4-chlorobenzoyl)-4-ethylsemicarbazide (23.7 g, 9.81×10-2 mole) and 1 molar aqueous NaOH (118 ml, 1.18×10-1 mole) were stirred and warmed to reflux. After refluxing 23 hours, heating was discontinued and the reaction was acidified by the dropwise addition of 1 molar aqueous hydrochloric acid (130 ml, 1.30×10-1 mole). A colorless solid formed as the reaction was acidified and, after cooling in an ice bath, this was collected by filtration. Crystallization from isopropanol gave colorless spars: 18.2 g (83%), mp 188°-189°.

後処理

  1. temperaturewarmed to reflux
  2. temperatureAfter refluxing 23 hours
  3. temperatureheating
  4. customA colorless solid formed as the reaction
  5. temperatureafter cooling in an ice bath
  6. filtrationthis was collected by filtration
  7. customCrystallization from isopropanol
  8. customgave colorless spars

出典と根拠

ORDレコード
ord-05f463c5982041c9b099d692c11048e4
出典データセット
uspto-grants-1990_08
特許番号
US04946856

反応ノート

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