Ammonium Chloride → HCID 178470518、化合物

反応式

[NH:1]1[C:5]([C:6]([OH:8])=[O:7])=[N:4][N:3]=[N:2]1.[C:9]([C:11](OCC)=O)#N.[N-]=[N+]=[N-].[Na+].[Cl-].[NH4+]>>[NH:1]1[C:5]([C:6]([O:8][CH2:9][CH3:11])=[O:7])=[N:4][N:3]=[N:2]1

参加物

反応物 4

HCID 25517Ammonium Chloride

HCID 33557Sodium Azide

HCID 69336Ethyl cyanoformate

HCID 178524966HCID 178524966、化合物

生成物 1

HCID 178470518HCID 178470518、化合物

実験手順

Tetrazole-5-carboxylic acid can be prepared by treating ethyl cyanoformate with sodium azide and ammonium chloride to form ethyl tetrazole-5-carboxylate, which is hydrolyzed with alkali (e.g., KOH) to give alkali tetrazole-5-carboxylate, according to the method described in J. Med. Chem. 19, 289(1976) and Ibid, 29, 538(1986).