Sodium Bicarbonate → HCID 178468139、化合物

HRID 1709195ノート

反応式

HRID 1709195 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1.[NH:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1)[C:15]([NH2:17])=[NH:16].[C:27]([O-:30])([OH:29])=[O:28].[Na+]>N1C=CC=CC=1>[C:27](=[O:28])([OH:30])[OH:29].[NH:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([O:1][C:2]2[CH:3]=[CH:4][C:5]([S:8][CH2:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:6][CH:7]=2)=[O:23])=[CH:20][CH:19]=1)[C:15]([NH2:17])=[NH:16]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 150272734-[(2-Ethoxyethyl)thio]phenolHCID 178512519HCID 178512519、化合物

生成物 1

HCID 178468139HCID 178468139、化合物収率 40%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3.4 g of 2-ethoxyethyl 4-hydroxyphenyl sulfide was dissolved in 50 ml of pyridine. 4-Guanidinobenzoyl chloride was added to the solution under cooling with ice and the mixture was stirred at room temperature for 27 h. A saturated aqueous solution of sodium hydrocarbonate was added thereto under cooling with ice. A precipitate thus formed was recovered by filtration, washed with water and then with acetone, and dried to obtain 2.86 g (yield: 40 %) of 4-(2-ethoxyethylthio)phenyl 4-guanidinobenzoate carbonate.

後処理

  1. temperatureunder cooling with ice
  2. temperatureunder cooling with ice
  3. customA precipitate thus formed
  4. filtrationwas recovered by filtration
  5. washwashed with water
  6. dry with materialwith acetone, and dried

出典と根拠

ORDレコード
ord-6cef8c273965478ab65e9f151f671b83
出典データセット
uspto-grants-1990_08
特許番号
US04948808

反応ノート

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