関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Pyridine, 2,4,6-trichloro- | HCID 27665 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2,6-Dichloro-N-methylpyridin-4-amine | HCID 19957394 | — |
反応手順
2,4,6-Trichloropyridine (1800 g, 9.89 mol) was dissolved in ethanol (1800 mL). Methylamine 40% solution in ethanol (6.3 L) was added over 1 h and 40 min maintaining the reaction temperature between 20-25° C. The reaction was stirred for 14 hours at room temperature and concentrated. The product was filtered, washed with methyl t-butyl ether (1,500 ml) and dried to yield A1.6 (1200 g, 68%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07737279B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-336a37a99c754ec081c44405c93b39d8 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
