Ethylene Glycol → Polyethylene glycol monocaprylate

Anhydride of caprylic acid (0.477 mol; 129 g) was dropwise added into boiling dry ethylene glycol (3.16 mol; 196 g) and the mixture was refluxed for further 4 hours. The mixture was cooled, extracted twice with benzene (100+20 ml), benzene was evaporated in a rotation evaporator, and the residue was distilled. 2-Hydroxyethyl caprylate was obtained in the yield of 142.75 g (159% of theory), which is the evidence that almost 2/3 of caprylic acid formed was esterified with glycol under the experimental conditions. The raw fractions had purity 88.9 to 97.5% of 2-hydroxyethyl caprylate. Further procedure was carried out according to example 1.

1. temperaturethe mixture was refluxed for further 4 hours
2. temperatureThe mixture was cooled
3. extractionextracted twice with benzene (100+20 ml), benzene
4. customwas evaporated in a rotation evaporator
5. distillationthe residue was distilled

ORDレコード

ord-d704a49c1ae44f66bd6a9553e55e7bf7

出典データセット

uspto-grants-1990_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04950733