Benzalkonium Chloride → Hydrochloric Acid

HRID 1709982

反応式

HRID 1709982 の反応式
C[C:2]([NH:5][CH2:6][C@H:7]([OH:21])[CH2:8][O:9][C:10]1[C:11](N2CCOCC2)=NSN=1)([CH3:4])[CH3:3].[CH:22](/[C:27]([OH:29])=O)=[CH:23]/[C:24](O)=O.CCCCCCCCCCCCC[N+]([CH2:46][C:47]1[CH:48]=[CH:49]C=[CH:51][CH:52]=1)(C)C.[Cl-:53]>O.[Na+].[Cl-]>[CH3:4][CH:2]([NH:5][CH2:6][CH:7]([OH:21])[CH2:8][O:9][C:10]1[CH:11]=[CH:46][C:47]([CH2:48][CH2:49][O:29][CH2:27][CH:22]2[CH2:23][CH2:24]2)=[CH:52][CH:51]=1)[CH3:3].[ClH:53].[ClH:53]

参加物

5

反応物 2

HCID 3014024Benzalkonium ChlorideHCID 5281056Timolol Maleate

生成物 2

HCID 313Hydrochloric AcidHCID 107952Betaxolol Hydrochloride

試薬・触媒・溶媒 1

HCID 57417360Sodium chloride; water溶媒

実験手順

Timolol maleate powder was from Merck, Sharp and Dohme (West Point, Pa.) and was dissolved in 0.5% polysorbate 80 in normal saline with 0.01% benzalkonium chloride (40 mg/ml, and 20 mg/ml, respectively). Betaxolol hydrochloride (Betoptic; Alcon, Fort Worth, Tex.) at a concentration of 0.5% (5 mg/ml) and levobunalol hydrochloride (Betagan; Allergan, Irvine, Calif.) at a concentration of 0.5% (5 mg/ml), were obtained from the pharmacy.

出典と根拠

ORDレコード
ord-7c2c3d85450b4229ba69dc8ec5a40455
出典データセット
uspto-grants-1990_08
特許番号
US04952581

関連ノート

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