Dimethylformamide → HCID 23035470、化合物
反応式
S(Cl)([Cl:3])=O.[N:5]1([CH2:11][C:12]2[CH:13]=[C:14]([CH:21]=[CH:22][CH:23]=2)[O:15][CH2:16][CH2:17][C:18](O)=[O:19])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.CN(C)C=O>ClCCl>[ClH:3].[N:5]1([CH2:11][C:12]2[CH:13]=[C:14]([CH:21]=[CH:22][CH:23]=2)[O:15][CH2:16][CH2:17][C:18]([Cl:3])=[O:19])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1参加物
5
実験手順
Thionyl chloride (23.8 g) was added slowly to a cooled (0° C.) mixture of 3-[3-(piperidinomethyl)phenoxy]propionic acid and dimethylformamide (0.5 ml) in dichloromethane (100 ml). The resulting suspension was stirred at room temperature overnight, and solvent was removed under reduced pressure to give 3-[3-(piperidinomethyl)phenoxy]propionyl chloride hydrochloride (18.9 g) as an oil.