Methanol → Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-
反応式
C([O:4][CH:5]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]#[C:12][CH2:13][N:14]([CH3:18])[C:15](=[O:17])[CH3:16])[CH2:6]1)(=O)C.C(=O)([O-])[O-].[Na+].[Na+].CO>ClCCl>[OH:4][CH:5]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]#[C:12][CH2:13][N:14]([CH3:18])[C:15](=[O:17])[CH3:16])[CH2:6]1参加物
5
実験手順
A mixture of 820 mg of (racemic)-N-[4-[3-(acetyloxy)-1-pyrrolidinyl]-2-butynyl]-N-methyl acetamide, 635 mg of sodium carbonate and 40 ml of methanol was stirred overnight. An equal volume of dichloromethane was added, the mixture filtered and the solvents concentrated. This residue was purified by chromatography (alumina), giving 500 mg of the desired product as a yellow oil.
後処理
- filtrationthe mixture filtered
- concentrationthe solvents concentrated
- customThis residue was purified by chromatography (alumina)
出典と根拠
- ORDレコード
- ord-e5b8326aa2434b0a833da132c5299aea
- 出典データセット
- uspto-grants-1990_08
- 特許番号
- US04952600
反応ノート
読み込み中…