HCID 86744189、化合物 → Pirazolac

HRID 1710200ノート

反応式

HRID 1710200 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([O-:23])=[O:22])=[N:9]2)=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([OH:23])=[O:22])=[N:9]2)=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 86744189HCID 86744189、化合物

生成物 1

HCID 51222Pirazolac

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

1,49 Grams (3 mM) of the benzohydryl [1-(4-fluorophenyl)-4-(4-chlorophenyl)-1H-pyrazol-3-yl]-acetate are dissolved in 40 ml of tetrahydroflurane. To the solution 0,4 g of Pd on charcoal (10%) are added, then the mixture is hydrogenated at room temperature and pressure. At the end of the reaction the catalysator is filtered, the solvent evaporated and the product crystallized from acetic acid/ethanol. The title product is obtained in almost quantitative yield.

後処理

  1. customis hydrogenated at room temperature
  2. customAt the end of the reaction the catalysator
  3. filtrationis filtered
  4. customthe solvent evaporated
  5. customthe product crystallized from acetic acid/ethanol

出典と根拠

ORDレコード
ord-f2ab52f269b44a928d2852f75c3558b9
出典データセット
uspto-grants-1990_08
特許番号
US04952702

反応ノート

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