Chloroacetyl chloride → 1-(2-Chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one
反応式
C(O)(=O)C.[Cl:5][C:6]1[C:7]([CH3:18])=[C:8]([N:12]2[C:16](=[O:17])[CH2:15][NH:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1.C([O-])([O-])=O.[K+].[K+].[Cl:25][CH2:26][C:27](Cl)=[O:28]>C(Cl)Cl.O>[Cl:25][CH2:26][C:27]([N:14]1[CH2:15][C:16](=[O:17])[N:12]([C:8]2[CH:9]=[CH:10][CH:11]=[C:6]([Cl:5])[C:7]=2[CH3:18])[CH2:13]1)=[O:28]参加物
5
実験手順
To a mixture of 3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one acetic acid salt (75) (422 mg, 1 equiv) and K2CO3 (552 mg) in 5 mL of DCM/water (1:1 v/v) was added chloroacetyl chloride (240 μL, 1.5 equiv). One hour later, the organic layer was separated and dried over sodium sulfate to give 1-(2-chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one (76).